Equianalgesic Tables
EQUIANALGESIC TABLE FOR CHRONIC OPIOID DOSING
DRUG | ORAL (PO) | PARENTERAL (SC, IV) |
---|---|---|
Morphine | 10 mg | 5 mg1 |
Codeine | 100 mg | 65 mg |
Hydromorphone | 2 mg | 1 mg2 |
Oxycodone | 5.0-7.5 mg | - |
Methadone | 1 mg but highly variable ratio & complex3 | Not readily available |
Fentanyl transdermal patch | 25 ug patch ≅ 60-134 mg oral morphine daily dose MEDD4 |
NOTE: Due to incomplete cross-tolerance between opioids, it is often necessary to reduce equivalent dose of new drug by 25% to 50%, and then titrate
RECOMMENDED INITIAL DOSE FOR OPIOID CONVERSION TO DURAGESIC® (FENTANYL) PATCH
Oral 24-hour morphine equivalent daily dose (MEDD mg/day) | (ug/hour) Duragesic® dose equivalent (ug/hour) |
---|---|
60-134 | 25 |
135-224 | 50 |
225-314 | 75 |
315-404 | 100 |
405-494 | 125 |
495-584 | 150 |
585-674 | 175 |
675-764 | 200 |
785-854 | 225 |
855-944 | 250 |
945-1034 | 275 |
SOURCES/REFERENCES
- Janssen-Ortho 2006
- Downing GM, Wainwright W, editors. Medical care of the dying. 4th ed. Victoria (BC): Victoria Hospice Society; 2006. p. 195,201.
page revision: 8, last edited: 29 Jun 2009 06:28